Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-3576
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10376933,
pubmed-article:10982368,
pubmed-article:11069235,
pubmed-article:11160671,
pubmed-article:12388718,
pubmed-article:16273337,
pubmed-article:16375755,
pubmed-article:16697675,
pubmed-article:17197385,
pubmed-article:17716703,
pubmed-article:17918746,
pubmed-article:18574677,
pubmed-article:19526283,
pubmed-article:22301094,
pubmed-article:7695626,
pubmed-article:9378998,
pubmed-article:9510190
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat downregulates IL-8 expression in the Raji B-cell line, however in the presence of PMA+PHA Tat induced IL-8 expression,
HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes,
HIV-1 Tat protein upregulates expression of IL-6 and IL-8 in human breast cancer cells by an NF-kappaB-dependent pathway,
HIV-1 Tat upregulates IL-8 and VEGF production and release from polymorphonuclear leukocytes (PMNL), indicating that PMNL recruitment by Tat is linked to angiogenesis,
HIV-1 Tat upregulates IL-8 expression in astrocytes, monocytes, monocyte derived macrophages, Jurkat T-cells, HeLa cells, and human brain endothelial cells, an effect that likely contributes to the immune dysregulation observed during HIV-1 infection,
HIV-1 Tat upregulation of IL-8 is linked to the cell cycle and involves NF-kappa B, RelA, c-rel, and CREB-binding protein,
Upregulation of IL-8 by HIV-1 Tat in astrocytes is inhibited by the MEK1/2 inhibitor UO126, indicating a role for MEK1/2 in Tat-mediated chemokine induction,
Upregulation of IL-8 by HIV-1 Tat is implicated in the pathogenesis of Kaposi's sarcoma
|
| entrezgene:keyphrase |
downregulates,
upregulates
|