Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-3575
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat and IL-7 act synergistically to downregulate CD127 on CD8+ T cells. Downregulation of CD127 by IL-7 requires JAK activation pathway,
HIV-1 Tat downregulates cell surface expression of IL-7R on human CD8 T-cells in a dose- and time-dependent manner,
HIV-1 Tat inhibits the effects of IL-7 on activation of CD8 T-cells signaling via IL-7R,
HIV-1 Tat upregulates the expression of IL-7R in human macrophages, which leads to the enhancement of HIV-1 replication,
HIV-1 Tat-mediated degradation of IL-7R alpha-chain (CD127) from the surface of resting CD8 T cells leads to reduced IL-7 signaling and to impaired CD8 T cell proliferation and function
|
| entrezgene:keyphrase |
inhibits,
downregulates,
upregulates,
degrades
|