Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-3447
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| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication,
HIV-1 Tat inhibits CpG-A-induced secretion of IFN-a and IFN- proteins in PBMCs,
HIV-1 Tat upregulates IFN-alpha secretion by macrophages, an effect that augments MIP-1alpha and MIP-1beta secretion and induces immunosuppression of uninfected T cells,
IFN treatment significantly reduces HIV-1 mRNA levels from a Tat defective provirus, suggesting Tat can overcome the inhibitory effects of IFN on HIV-1 replication
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| entrezgene:keyphrase |
inhibits,
interacts with,
upregulates
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