Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-3135
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat 47-59 peptide downregulates gene expression of HLA-G histocompatibility antigen, class I, G (HLA-G) in U-937 macrophages,
HIV-1 Tat represses the MHC class I gene promoter by binding to and repressing TAFII250, a component of the general transcription factor TFIID, suggesting a mechanism for HIV-1 to downregulate MHC class I expression and avoid immune surveillance,
HIV-1 Tat upregulates MHC class I in monocyte-derived dendritic cells and CD8(+) T cells, thereby driving T cell-mediated immune responses
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| entrezgene:keyphrase |
downregulates,
upregulates
|