Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-2902
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10197777,
pubmed-article:11483648,
pubmed-article:11606043,
pubmed-article:12414113,
pubmed-article:12753088,
pubmed-article:12775422,
pubmed-article:14644469,
pubmed-article:16489129,
pubmed-article:16697675,
pubmed-article:17360663,
pubmed-article:19020013,
pubmed-article:19036954,
pubmed-article:19526283,
pubmed-article:21948112,
pubmed-article:22552781,
pubmed-article:22940423,
pubmed-article:7695237,
pubmed-article:9651389
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Ca(2+) influx through the NMDA receptor is necessary for HIV-1 Tat-induced synapse loss,
HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death,
HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors,
HIV-1 Tat interacts with NMDA receptors in primary neuronal-glial cultures and in hippocampal slice cultures,
HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface,
HIV-1 Tat upregulates expression of NMDA receptor 1 in mixed cultures of human neurons and astrocytes,
HIV-1 Tat-induced NMDA receptor activation is clade dependent. The Cys 30-Cys 31 motif in Tat is critical for the NMDA receptor activation,
Tat treatment causes activation of neuronal nitric oxide synthase (nNOS) through association with NMDA receptors
|
| entrezgene:keyphrase |
inhibits,
interacts with,
upregulates,
associates with,
activates,
induces complex with
|