Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-1958
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat binds to Egr-1, an interaction that is mediated through Tat amino acids 30-40,
HIV-1 Tat decreases the levels of Egr-1 and p35 expression in nerve growth factor (NGF)-treated neural cells,
HIV-1 Tat increases Egr-1 expression in human astrocytoma cells by transactivating the Egr-1 promoter and involving specific serum response elements within the promoter,
HIV-1 Tat upregulates EGR1 expression in Tat-infected Jurkat T cells,
HIV-1 Tat-induced upregulation of p300 occurs at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter,
HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1)
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| entrezgene:keyphrase |
downregulates,
cooperates with,
upregulates,
binds,
activated by
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