Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-142
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| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat induces the cleavage of PARP and activation of apoptosis through a p56lck dependent mechanism,
PARP1 negatively regulates HIV-1 transcription by directly competing with Tat-P-TEFb complex for binding to TAR RNA,
Poly(ADP-ribose) polymerase modifies HIV-1 Tat with poly(ADP-ribose), suggesting a role for this enzyme in the regulation of HIV-1 gene expression,
Purified recombinant HIV-1 Tat protein stimulates poly(ADP-ribose) polymerase in a dose dependent manner,
The levels of PARP1 protein are reduced after Caco-2 cells exposure to HIV-1 Tat compared with control,
The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal,
Treatment of primary human microvascular endothelial cells of lung origin with HIV-1 Tat caused cleavage of poly(A/DP)-ribose polymerase as a result of caspase activation
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| entrezgene:keyphrase |
interacts with,
regulated by,
stimulates,
induces cleavage of,
regulates,
modified by
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