Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-10524
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10096020,
pubmed-article:10393559,
pubmed-article:11275565,
pubmed-article:12154097,
pubmed-article:16001085,
pubmed-article:18577246,
pubmed-article:19114310,
pubmed-article:19716452,
pubmed-article:21320689,
pubmed-article:21320693,
pubmed-article:22391203,
pubmed-article:8607265,
pubmed-article:9388189
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position,
HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage,
HIV-1 Tat inhibits Tip60 histone-acetyltransferase activity and abolishes Tip60-dependent transcriptional activity of the Mn-SOD promoter,
Reduced levels of Tip60 by HIV-1 Tat is sufficient to restore the effectiveness of antiviral drug maribivar to inhibit -herpes virus human cytomegalovirus,
Tip60 enhances HIV-1 Tat activation of the HIV-1 LTR promoter in HeLa cells,
Tip60 inhibits HIV-1 Tat activation of the HIV-1 LTR promoter in Jurkat cells,
Tip60 is a nuclear histone acetyltransferase that binds to the N-terminal 31 amino acids of HIV-1 Tat
|
| entrezgene:keyphrase |
inhibits,
downregulates,
inhibited by,
binds,
complexes with,
enhanced by,
degrades
|