Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-1022
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10066804,
pubmed-article:10082552,
pubmed-article:10438593,
pubmed-article:10639311,
pubmed-article:10866664,
pubmed-article:12049628,
pubmed-article:14569024,
pubmed-article:19732026,
pubmed-article:8628270,
pubmed-article:8849451,
pubmed-article:8934526,
pubmed-article:9054383,
pubmed-article:9121429,
pubmed-article:9184228,
pubmed-article:9311822,
pubmed-article:9334327,
pubmed-article:9570510,
pubmed-article:9651670,
pubmed-article:9765201
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Amino acids 1-48 of HIV-1 Tat, which includes the Tat activation domain, mediate the binding of Tat to CAK and the TFIIH complex through a direct interaction with CDK7 and possibly other TFIIH subunits, including p62 and ERCC3,
CAK/TFIIH is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter,
HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIH, during Tat-mediated transactivation of the HIV-1 LTR,
Interaction of HIV-1 Tat with TFIIH stimulates phosphorylation of Ser-5 of the RNA polymerase II C-terminal domain (CTD), which in turn also stimulates co-transcriptional capping of HIV-1 mRNA,
Phosphorylation of CDK7 by CDK2 is involved in the interaction of HIV-1 Tat with CDK7 and subsequent activation of HIV-1 transactivation of the HIV-1 LTR promoter,
TFIIH interacts with HIV-1 Tat as a component of the HIV-1 transcription preinitiation complex, but is released from the elongation complex which includes P-TEFb,
TFIIH subunits CDK7 and cyclin H have been identified as two components associated with the Tat-associated CTD kinase (TTK) that binds to HIV-1 Tat,
TFIIH synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter
|
| entrezgene:keyphrase |
interacts with,
requires,
binds,
stimulates,
synergizes with
|