Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155807-983
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10958988,
pubmed-article:11531413,
pubmed-article:11878934,
pubmed-article:12525641,
pubmed-article:15142377,
pubmed-article:15265780,
pubmed-article:15578977,
pubmed-article:15725353,
pubmed-article:15780175,
pubmed-article:15817944,
pubmed-article:16354571,
pubmed-article:17433108,
pubmed-article:17586317,
pubmed-article:18445273,
pubmed-article:18514189,
pubmed-article:19275580,
pubmed-article:19275583,
pubmed-article:19275586,
pubmed-article:19275588,
pubmed-article:19344781,
pubmed-article:19458171,
pubmed-article:21489275,
pubmed-article:21918813,
pubmed-article:7474080,
pubmed-article:7474100,
pubmed-article:7494303,
pubmed-article:7666531,
pubmed-article:9094673,
pubmed-article:9188632,
pubmed-article:9520381,
pubmed-article:9560267
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Accumulation of the hypophosphorylated or active form of cdc2 kinase is not required for HIV-1 Vpr-induced apoptosis, however one report indicates cdc2 is activated in Vpr-induced apoptotic cells,
Data suggests that HIV-1 Vpr transactivation of the HIV-LTR promoter occurs through the inhibition of p300-associated cdc2-cyclin B kinase complex activity which enhances transcriptional activation by Rel A and p300,
HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta,
HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2,
HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inhibiting the dephosphorylation of cdc2 tyrosine 15, leading to arrest in the G2 phase of the cell cycle,
Inactivation of the cdc2-cyclin B kinase complex and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96,
Inactivation of the cdc2-cyclin B kinase complex by HIV-1 Vpr leads to the activation of Poly(A) polymerase,
The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex and induction of cell cycle arrest,
Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta
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| entrezgene:keyphrase |
inhibits,
interacts with,
activates,
inactivates
|