Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155807-7157
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Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53,
Exposure of cultured human primary astrocytes to HIV-1 Vpr induces p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury,
HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity,
HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks,
HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter,
Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr,
Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21,
Soluble HIV-1 Vpr causes neuronal apoptosis, involving cytochrome c extravasation, p53 induction, and activation of caspase-9
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| entrezgene:keyphrase |
inhibits,
interacts with,
regulated by,
upregulates,
activates
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