Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155807-5520
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| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain,
HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues,
HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A,
HIV-1 Vpr was found to upregulate PP2A in fission yeast
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| entrezgene:keyphrase |
upregulates,
binds,
activates
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