Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155030-801
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| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
An HIV-1 MA peptide (residues 8-43) binds to CaM with a very high affinity with dissociation constant 25 nm,
Calmodulin (CaM) binding to HIV-1 MA induces the extrusion of the myristate group, suggesting that hydrophobic contacts between CaM and MA are critical for binding,
Calmodulin binds to both HIV-1 Gag and Matrix proteins through an extended calmodulin-binding domain in Matrix (amino acids 11-46),
The two buried tryptophan's (W16 and W36), which located in the first two alpha-helices of MA, mediate the calmodulin interaction
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| entrezgene:keyphrase |
interacts with,
binds
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