Source:http://linkedlifedata.com/resource/#_513957555835002B
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Mice lacking coiled-coil region N-terminal part exhibit disruption of Mrvi1-Itpr1 interaction. They have dilated gastrointestinal tract and disturbed gastrointestinal motility. Smooth muscle are no more relaxed by cGMP after phenilephrine-induced contraction and half of the homozygous mice dies before the age of 6 months. Nitric oxide (NO) and cGMP-mediated inhibition of collagen-induced platelet aggregation is strongly suppressed in platelets of these transgenic mice. growth.
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