Source:http://linkedlifedata.com/resource/#_5030373238310025
| Predicate | Object |
|---|---|
| rdf:type | |
| uniprot:attribution | |
| rdf:subject | |
| rdf:predicate | |
| rdf:object |
Disruption of a single RPS19 gene reduces cell growth; a double disruption is lethal. Depletion experiments show the proteins are required for correct maturation of precursor rRNA to generate the 18S small rRNA. A specific site between the 18S and 5.8S precursors (site A2 in ETS1) is not cleaved in disruption mutants. Partially assembled ribosomes are retained in the nucleolus rather than being exported to the cytoplasm. All effects are exacerbated in the double disruption. Increases association of NOC4 with 20/21S pre-rRNA, decreases association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.
|