Source:http://linkedlifedata.com/resource/#_503031393033007E
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http://linkedlifedata.com/resource/#_503031393033007F,
http://linkedlifedata.com/resource/#_5030313930330080,
http://linkedlifedata.com/resource/#_5030313930330081,
http://linkedlifedata.com/resource/#_5030313930330082,
http://linkedlifedata.com/resource/#_5030313930330083,
http://linkedlifedata.com/resource/#_5030313930330084
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Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
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