Source:http://linkedlifedata.com/resource/#_4F34323236310022
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Primarily expressed in the developing central nervous system (CNS). At gastrula stage, expressed in both the superficial and deep layers of the presumptive neural plate with expression spreading to the prospective hindbrain, spinal cord and midbrain-hindbrain junction as neurulation proceeds. Not expressed in the anterior neural plate and CNS expression in the tadpole excludes the forebrain. Outside of the CNS, expressed around the closing blastopore at early gastrula stages and as gastrulation proceeds, expression switches to the anterior lateral plate mesoderm. In tadpoles, expressed in the ectodermal layer of the branchial arches, and in the otic vesicle. Also expressed in specific and overlapping dynamic patterns with irx1 and irx2 during pronephric kidney development. Renal expression begins before segment-specific terminal differentiation in the pronephric anlage at mid-neurula stage, and is later found in proximal tubule PT3 as well as intermediate tubule segments IT1 and IT2, with expression in the kidney being maintained through to the tadpole stage.
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