Source:http://linkedlifedata.com/resource/#_42375A514A390027
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There is conflicting evidence as to whether gtf2ird1 acts as a transcriptional activator or repressor when directly bound to the distal element of the gsc promoter. PubMed:11937490 shows that gtf2ird1 acts cooperatively with smads and foxh1/fast1 to activate activin/nodal-mediated gsc transcription. However, PubMed:16055724 report that in the absence of TGF-beta, gtf2ird1 represses gsc transcription. Upon TGF-beta stimulation, smad2 is translocated to the nucleus as a complex with smad4, interacts with TFII-I, and binds to the distal element to dislodge gtf2ird1 and up-regulate gsc gene transcription.
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