Q9Z1T6

FUNCTION: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 3- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. SUBUNIT: Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane (By similarity). Note=Associated with vesicle structures. Displays a peripheral vesicular punctate pattern. Mainly associated with membranes of the late endocytic pathway (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=p235S; IsoId=Q9Z1T6-2; Sequence=Displayed; Name=2; Synonyms=p235L; IsoId=Q9Z1T6-1; Sequence=VSP_034953, VSP_034954; Name=3; IsoId=Q9Z1T6-3; Sequence=VSP_034955, VSP_034956; TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 1 DEP domain. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 PIPK domain. SEQUENCE CAUTION: Sequence=AAD10191.1; Type=Frameshift; Positions=Several; Sequence=BAB30626.3; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD32355.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:Pikfyve Kiaa0981 Pip5k3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 2097 AA; 236877 MW; 8C529E86FBEED8E6 CRC64;

FYV1_MOUSE

urn:biopax:ModificationFeature:FYV1_MOUSE_1, urn:biopax:ModificationFeature:FYV1_MOUSE_10, urn:biopax:ModificationFeature:FYV1_MOUSE_11, urn:biopax:ModificationFeature:FYV1_MOUSE_12, urn:biopax:ModificationFeature:FYV1_MOUSE_13, urn:biopax:ModificationFeature:FYV1_MOUSE_14, urn:biopax:ModificationFeature:FYV1_MOUSE_15, urn:biopax:ModificationFeature:FYV1_MOUSE_16, urn:biopax:ModificationFeature:FYV1_MOUSE_17, urn:biopax:ModificationFeature:FYV1_MOUSE_18, urn:biopax:ModificationFeature:FYV1_MOUSE_19, urn:biopax:ModificationFeature:FYV1_MOUSE_2, urn:biopax:ModificationFeature:FYV1_MOUSE_20, urn:biopax:ModificationFeature:FYV1_MOUSE_21, urn:biopax:ModificationFeature:FYV1_MOUSE_22, urn:biopax:ModificationFeature:FYV1_MOUSE_23, urn:biopax:ModificationFeature:FYV1_MOUSE_24, urn:biopax:ModificationFeature:FYV1_MOUSE_25, urn:biopax:ModificationFeature:FYV1_MOUSE_26, urn:biopax:ModificationFeature:FYV1_MOUSE_27, urn:biopax:ModificationFeature:FYV1_MOUSE_28, urn:biopax:ModificationFeature:FYV1_MOUSE_29, urn:biopax:ModificationFeature:FYV1_MOUSE_3, urn:biopax:ModificationFeature:FYV1_MOUSE_30, urn:biopax:ModificationFeature:FYV1_MOUSE_31, urn:biopax:ModificationFeature:FYV1_MOUSE_4, urn:biopax:ModificationFeature:FYV1_MOUSE_5, urn:biopax:ModificationFeature:FYV1_MOUSE_6, urn:biopax:ModificationFeature:FYV1_MOUSE_7, urn:biopax:ModificationFeature:FYV1_MOUSE_8, urn:biopax:ModificationFeature:FYV1_MOUSE_9

MATDDKSSPTLDSANDLPRSPASPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERGEGGQGEQQSPSSSWASPQIPSRTQSVRSPVPYKKQLNEELHRRSSVLDSRRKAEPACGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSTCSVSILDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNSALSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRNYIRTETTEDERKILLDSAQLKDLWKKICHHTSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLVSDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENEEKQAMERLLSANHNHMMALLQQLLQNESLSSSWRDIIVSLVCQVVQTVRPDVKHQDDDMDIRQFVHIKKIPGGKKFDSVVVNGFVCTKNIAHKKMNSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVVSMDQLLTKPHLGTCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMPPTLMQSPSFHLLTEGRGEEGASQEQVSGSSLPQDPECPREALSSEDSTLLESRTVLEKGELDNKSIPQAVASLKHQDYTTPTCPAGIPCALFALVPESLLPLHMDQQDAVGNEQPETSQQTDEQQDPKSQMKAFRDPLQDDTGMYVTEEVTSSEDQRKTYALTFKQELKDVILCISPVITFREPFLLTEKGMRCSTRDYFPEQIYWSPLLNKEVKEMESRRKKQLLRDLSGLQGMNGSVQAKSIQVLPSHELVSTRIAEHLGDSQTLGRMLADYRARGGRIQSKHLDPFVHSKDASCTSGGKSGNKTESDEERGLIPSDVIWPTKVDCLNPANHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLERYCFRSSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPGYQHTILTYSWCRICKQVTPVVALSNESWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHHDYHQYFSYNQMVASFSYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLKDFFQKVSQVYLAVDERLASLKTDTFSKTREEKMEDIFAQKEMEEGEFKNWTEKMQARLMSSSVDTPQQLQSIFESLIAKKQSLCEVLQAWNSRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKINAMDTSPRNISPGLHNGEKEDRFLTTLSSQSSTSSTHLQLPTPPEALAEQVVGGPTDLDSASGSEDVFDGHLLGSTDSQVKEKSTMKAIFANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRNALEELSKATLRNSAEEGLPANSALDNRPKSSSPIRLPEISGGQTNRTVEAEPQPTKKASGMLSFFRGTAGKSPDLSSQKRETLRGADSAYYQVGQAGKEGLESQGLEPQDEVDGGDTQKKQLTNPHVELQFSDANAKFYCRLYYAGEFHKMREVILGSSEEEFIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKSVLRTSIHSDAHFLSSHLIIDYSLLVGRDDTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGLDLNC