| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. COFACTOR: Binds 6 copper ions per monomer (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z0Z4-1; Sequence=Displayed; Name=2; IsoId=Q9Z0Z4-2; Sequence=VSP_011628; DISEASE: Note=Defects in Heph are a cause of the sex-linked anemia (sla) that is characterized by moderate to severe microcytic hypochronic anemia. SIMILARITY: Belongs to the multicopper oxidase family. SIMILARITY: Contains 6 plastocyanin-like domains. SEQUENCE CAUTION: Sequence=BAC98004.1; Type=Erroneous initiation; GENE SYNONYMS:Heph Kiaa0698. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1157 AA; 129666 MW; 41055EC4DA11DC12 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:MOUSE GENOME DATABASE_MGI:1332240,
urn:biopax:RelationshipXref:NCBI GENE_15203,
urn:biopax:RelationshipXref:REFSEQ_NP_001153099,
urn:biopax:RelationshipXref:REFSEQ_NP_001153100,
urn:biopax:RelationshipXref:REFSEQ_NP_034547,
urn:biopax:RelationshipXref:REFSEQ_NP_851790,
urn:biopax:UnificationXref:UNIPROT_A2AI63,
urn:biopax:UnificationXref:UNIPROT_Q6ZQ65,
urn:biopax:UnificationXref:UNIPROT_Q80Y80,
urn:biopax:UnificationXref:UNIPROT_Q8C4S2,
urn:biopax:UnificationXref:UNIPROT_Q9Z0Z4
|
| biopax3:displayName |
HEPH_MOUSE
|
| biopax3:name |
1.-.-.-,
Heph
|
| biopax3:organism | |
| biopax3:sequence |
MKAGHLLWALLLMHSLWSIPTDGAIRNYYLGIQDMQWNYAPKGRNVITNQTLNNDTVASSFLKSGKNRIGSSYKKTVYKEYSDGTYTEEIAKPAWLGFLGPLLQAEVGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWSIPESHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDGNSPPQRKDVDHNFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGAFQDSNRMHAINGFVFGNLPELSMCAQKHVAWHLFGMGNEIDVHTAFFHGQMLSIRGHHTDVANIFPATFVTAEMVPQKSGTWLISCEVNSHLRSGMQAFYKVDSCSMDPPVDQLTGKVRQYFIQAHEIQWDYGPIGYDGRTGKSLREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERVHQEEETHLGILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKNSEGTVYNDGTSHPKVAKSFEKVTYYWTVPPHAGPTAQDPACLTWMYFSAADPTRDTNSGLVGPLLVCKAGALGADGKQKGVDKEFFLLFTVFDENESWYNNANQAAGMLDSRLLSEDVEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFEGNTVQLQGMRKGAVMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREEGMQAIYNVSQCSSHQDSPRQHYQASRVYYIMAEEIEWDYCPDRSWELEWHNTSEKDSYGHVFLSNKDGLLGSKYKKAVFREYTDGTFRIPRPRSGPEEHLGILGPLIRGEVGDILTVVFKNKASRPYSIHAHGVLESNTGGPQAAEPGEVLTYQWNIPERSGPGPSDSACVSWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGGRNDMDREFALLFLIFDENQSWYLKENIATYGPQESSHVNLKDATFLESNKMHAINGKLYANLRGLTVYQGERVAWYMLAMGQDTDIHTVHFHAESFLYQNGQSYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETIFTVLSHEEHFSTMTTITKEIGKAVILRDIGGDNVKMLGMNIPIKDVEILSSALIAICVLLLLIALALGGVVWYQHRQRKLRRNRRSILDDSFKLLSLKQ
|
| biopax3:standardName |
Hephaestin
|