| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Inhibited by triazolodiamine 1, 5-amino-3-{[4- (aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4- triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3- chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3- methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3- chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3- chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=3; IsoId=Q9Y6M4-1; Sequence=Displayed; Name=2; Synonyms=3L, CSNK1G3L; IsoId=Q9Y6M4-2; Sequence=VSP_004749; Name=3; IsoId=Q9Y6M4-3; Sequence=VSP_010256, VSP_004749; Note=Phosphorylated on Ser-365 and Ser-366; PTM: Autophosphorylated (By similarity). MISCELLANEOUS: Triazolodiamine 1 is a commercial name for 5-amino- 3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H- 1,2,4-triazole-1-carbothioamide. SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS:CSNK1G3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 447 AA; 51389 MW; 6FAEDD605579ED3A CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2456,
urn:biopax:RelationshipXref:NCBI GENE_1456,
urn:biopax:RelationshipXref:REFSEQ_NP_001026982,
urn:biopax:RelationshipXref:REFSEQ_NP_001038187,
urn:biopax:RelationshipXref:REFSEQ_NP_001038188,
urn:biopax:RelationshipXref:REFSEQ_NP_004375,
urn:biopax:UnificationXref:UNIPROT_Q86WZ7,
urn:biopax:UnificationXref:UNIPROT_Q9Y6M3,
urn:biopax:UnificationXref:UNIPROT_Q9Y6M4
|
| biopax3:displayName |
KC1G3_HUMAN
|
| biopax3:name |
2.7.11.1,
CKI-gamma 3,
CSNK1G3
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:KC1G3_HUMAN_1,
urn:biopax:ModificationFeature:KC1G3_HUMAN_2,
urn:biopax:ModificationFeature:KC1G3_HUMAN_3,
urn:biopax:ModificationFeature:KC1G3_HUMAN_4,
urn:biopax:ModificationFeature:KC1G3_HUMAN_5,
urn:biopax:ModificationFeature:KC1G3_HUMAN_6,
urn:biopax:ModificationFeature:KC1G3_HUMAN_7,
urn:biopax:ModificationFeature:KC1G3_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQRHK
|
| biopax3:standardName |
Casein kinase I isoform gamma-3
|