| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP. SUBUNIT: Interacts with MAGI2. SUBCELLULAR LOCATION: Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane (By similarity). TISSUE SPECIFICITY: Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta. PTM: Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 cyclic nucleotide-binding domain. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 Ras-GEF domain. SEQUENCE CAUTION: Sequence=BAA20772.2; Type=Erroneous initiation; GENE SYNONYMS:RAPGEF2 KIAA0313 NRAPGEP PDZGEF1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1499 AA; 167417 MW; 1909E8A12637E001 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
RPGF2_HUMAN
|
| biopax3:name |
Neural RAP guanine nucleotide exchange protein,
PDZ domain-containing guanine nucleotide exchange factor 1,
PDZ-GEF1,
RA-GEF,
RAPGEF2,
nRap GEP
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:RPGF2_HUMAN_1,
urn:biopax:ModificationFeature:RPGF2_HUMAN_10,
urn:biopax:ModificationFeature:RPGF2_HUMAN_2,
urn:biopax:ModificationFeature:RPGF2_HUMAN_3,
urn:biopax:ModificationFeature:RPGF2_HUMAN_4,
urn:biopax:ModificationFeature:RPGF2_HUMAN_5,
urn:biopax:ModificationFeature:RPGF2_HUMAN_6,
urn:biopax:ModificationFeature:RPGF2_HUMAN_7,
urn:biopax:ModificationFeature:RPGF2_HUMAN_8,
urn:biopax:ModificationFeature:RPGF2_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
|
| biopax3:standardName |
Rap guanine nucleotide exchange factor 2
|