| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells. SUBUNIT: Homodimer; disulfide-linked. When phosphorylated, interacts with PTPN11/SHP2, GRB2 and CSK. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. PTM: Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK. CAUTION: In contrast to its orthologs it harbors a signal sequence. GENE SYNONYMS:SIT1 SIT. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 196 AA; 21126 MW; 2A0C48C9466F7F07 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
SIT1_HUMAN
|
| biopax3:name |
SHP2-interacting transmembrane adapter protein,
SIT1,
Suppression-inducing transmembrane adapter 1,
gp30/40
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:SIT1_HUMAN_1,
urn:biopax:ModificationFeature:SIT1_HUMAN_10,
urn:biopax:ModificationFeature:SIT1_HUMAN_11,
urn:biopax:ModificationFeature:SIT1_HUMAN_12,
urn:biopax:ModificationFeature:SIT1_HUMAN_13,
urn:biopax:ModificationFeature:SIT1_HUMAN_2,
urn:biopax:ModificationFeature:SIT1_HUMAN_3,
urn:biopax:ModificationFeature:SIT1_HUMAN_4,
urn:biopax:ModificationFeature:SIT1_HUMAN_5,
urn:biopax:ModificationFeature:SIT1_HUMAN_6,
urn:biopax:ModificationFeature:SIT1_HUMAN_7,
urn:biopax:ModificationFeature:SIT1_HUMAN_8,
urn:biopax:ModificationFeature:SIT1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MNQADPRLRAVCLWTLTSAAMSRGDNCTDLLALGIPSITQAWGLWVLLGAVTLLFLISLAAHLSQWTRGRSRSHPGQGRSGESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIPGPGTPVKYSEVVLDSEPKSQASGPEPELYASVCAQTRRARASFPDQAYANSQPAAS
|
| biopax3:standardName |
Signaling threshold-regulating transmembrane adapter 1
|