| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. SUBUNIT: Interacts with KCNN4, MTMR7, MTMR8 and MTMR9. SUBCELLULAR LOCATION: Nucleus envelope. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y217-1; Sequence=Displayed; Name=2; IsoId=Q9Y217-2; Sequence=VSP_036614, VSP_036615; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in CD4+ T-cells. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. SIMILARITY: Contains 1 myotubularin phosphatase domain. GENE SYNONYMS:MTMR6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 621 AA; 71968 MW; 1F34608F99DCEA39 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7453,
urn:biopax:RelationshipXref:NCBI GENE_9107,
urn:biopax:RelationshipXref:REFSEQ_NP_004676,
urn:biopax:UnificationXref:UNIPROT_B2RBB5,
urn:biopax:UnificationXref:UNIPROT_B3KSB4,
urn:biopax:UnificationXref:UNIPROT_Q5JRG6,
urn:biopax:UnificationXref:UNIPROT_Q86TB7,
urn:biopax:UnificationXref:UNIPROT_Q86YH4,
urn:biopax:UnificationXref:UNIPROT_Q96P80,
urn:biopax:UnificationXref:UNIPROT_Q9Y217
|
| biopax3:displayName |
MTMR6_HUMAN
|
| biopax3:name |
3.1.3.-,
MTMR6
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC
|
| biopax3:standardName |
Myotubularin-related protein 6
|