Q9UQC2

FUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. SUBUNIT: Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQC2-1; Sequence=Displayed; Name=2; IsoId=Q9UQC2-2; Sequence=VSP_038520; DOMAIN: The SH3-binding motifs mediate interaction with SHC1 and GRB2 (By similarity). DOMAIN: The PH domain mediates phosphatidylinositol 3,4,5- trisphosphate and phosphatidylinositol 3,4-bisphosphate binding (By similarity). PTM: Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. PTM: Dephosphorylated by PTPN11. SIMILARITY: Belongs to the GAB family. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAA25497.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:GAB2 KIAA0571. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 676 AA; 74458 MW; 107623FD07D884C9 CRC64;

GAB2_HUMAN

urn:biopax:ModificationFeature:GAB2_HUMAN_1, urn:biopax:ModificationFeature:GAB2_HUMAN_10, urn:biopax:ModificationFeature:GAB2_HUMAN_11, urn:biopax:ModificationFeature:GAB2_HUMAN_12, urn:biopax:ModificationFeature:GAB2_HUMAN_13, urn:biopax:ModificationFeature:GAB2_HUMAN_14, urn:biopax:ModificationFeature:GAB2_HUMAN_15, urn:biopax:ModificationFeature:GAB2_HUMAN_16, urn:biopax:ModificationFeature:GAB2_HUMAN_17, urn:biopax:ModificationFeature:GAB2_HUMAN_18, urn:biopax:ModificationFeature:GAB2_HUMAN_19, urn:biopax:ModificationFeature:GAB2_HUMAN_2, urn:biopax:ModificationFeature:GAB2_HUMAN_20, urn:biopax:ModificationFeature:GAB2_HUMAN_21, urn:biopax:ModificationFeature:GAB2_HUMAN_22, urn:biopax:ModificationFeature:GAB2_HUMAN_23, urn:biopax:ModificationFeature:GAB2_HUMAN_24, urn:biopax:ModificationFeature:GAB2_HUMAN_25, urn:biopax:ModificationFeature:GAB2_HUMAN_26, urn:biopax:ModificationFeature:GAB2_HUMAN_27, urn:biopax:ModificationFeature:GAB2_HUMAN_3, urn:biopax:ModificationFeature:GAB2_HUMAN_4, urn:biopax:ModificationFeature:GAB2_HUMAN_5, urn:biopax:ModificationFeature:GAB2_HUMAN_6, urn:biopax:ModificationFeature:GAB2_HUMAN_7, urn:biopax:ModificationFeature:GAB2_HUMAN_8, urn:biopax:ModificationFeature:GAB2_HUMAN_9

MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL