Linked Life Data

Q9UQ88

Source:http://identifiers.org/uniprot/Q9UQ88

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it (By similarity). SUBUNIT: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing, Alternative initiation; Named isoforms=8; Comment=Additional isoforms seem to exist; Name=SV6; Synonyms=p110; IsoId=Q9UQ88-1; Sequence=Displayed; Name=SV1; Synonyms=Pbeta21, Beta 2-1; IsoId=Q9UQ88-2; Sequence=VSP_008286, VSP_008288; Note=Ref.1 (AAA19594) sequence is in conflict in positions: 109:C->R, 112:H->R; Name=SV2; Synonyms=Pbeta22; IsoId=Q9UQ88-3; Sequence=VSP_008287, VSP_008288; Note=Ref.1 (AAA19595) sequence is in conflict in position: 158:F->V; Name=SV3; IsoId=Q9UQ88-4; Sequence=VSP_008288; Name=SV7; Synonyms=SV8; IsoId=Q9UQ88-5; Sequence=VSP_008283, VSP_008289; Name=SV12; IsoId=Q9UQ88-8; Sequence=VSP_008284, VSP_008292; Name=SV13; IsoId=Q9UQ88-9; Sequence=VSP_008281, VSP_008287, VSP_008288, VSP_008290, VSP_008291; Name=4; Synonyms=Beta 1, p58; IsoId=Q9UQ88-10; Sequence=VSP_018836; Note=Produced by alternative initiation at Met-345 of isoform SV6; TISSUE SPECIFICITY: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. INDUCTION: The p58 isoform is specifically induced in G2/M phase of the cell cycle. PTM: During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins. MISCELLANEOUS: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C- termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. CAUTION: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each. SEQUENCE CAUTION: Sequence=AAC95297.1; Type=Erroneous gene model prediction; Sequence=AAC95298.1; Type=Erroneous gene model prediction; Sequence=AAC95299.1; Type=Erroneous gene model prediction; Sequence=AAC95300.1; Type=Erroneous gene model prediction; Sequence=AAC95302.1; Type=Erroneous gene model prediction; Sequence=AAC95303.1; Type=Erroneous gene model prediction; GENE SYNONYMS:CDK11A CDC2L2 CDC2L3 PITSLREB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 783 AA; 91362 MW; 1BCF67EB180F37C6 CRC64;
biopax3:xref
urn:biopax:RelationshipXref:HGNC_HGNC:1730, urn:biopax:RelationshipXref:NCBI GENE_728642, urn:biopax:RelationshipXref:REFSEQ_NP_076916, urn:biopax:RelationshipXref:REFSEQ_NP_277071, urn:biopax:UnificationXref:UNIPROT_O95227, urn:biopax:UnificationXref:UNIPROT_O95228, urn:biopax:UnificationXref:UNIPROT_O96012, urn:biopax:UnificationXref:UNIPROT_Q12821, urn:biopax:UnificationXref:UNIPROT_Q12853, urn:biopax:UnificationXref:UNIPROT_Q12854, urn:biopax:UnificationXref:UNIPROT_Q2TAJ0, urn:biopax:UnificationXref:UNIPROT_Q5QPR0, urn:biopax:UnificationXref:UNIPROT_Q5QPR1, urn:biopax:UnificationXref:UNIPROT_Q5QPR2, urn:biopax:UnificationXref:UNIPROT_Q9UBC4, urn:biopax:UnificationXref:UNIPROT_Q9UBI3, urn:biopax:UnificationXref:UNIPROT_Q9UEI1, urn:biopax:UnificationXref:UNIPROT_Q9UEI2, urn:biopax:UnificationXref:UNIPROT_Q9UP53, urn:biopax:UnificationXref:UNIPROT_Q9UP54, urn:biopax:UnificationXref:UNIPROT_Q9UP55, urn:biopax:UnificationXref:UNIPROT_Q9UP56, urn:biopax:UnificationXref:UNIPROT_Q9UQ86, urn:biopax:UnificationXref:UNIPROT_Q9UQ87, urn:biopax:UnificationXref:UNIPROT_Q9UQ88, urn:biopax:UnificationXref:UNIPROT_Q9UQ89
biopax3:displayName
CD11A_HUMAN
biopax3:name
2.7.11.22, CDK11A, Cell division cycle 2-like protein kinase 2, Cell division protein kinase 11A, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L2
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
biopax3:standardName
Cyclin-dependent kinase 11A