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biopax3:comment |
FUNCTION: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA. SUBUNIT: Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex. SUBCELLULAR LOCATION: Nucleus speckle. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UQ35-1; Sequence=Displayed; Name=2; IsoId=Q9UQ35-2; Sequence=VSP_020187; Note=No experimental confirmation available; Name=3; IsoId=Q9UQ35-3; Sequence=VSP_020184, VSP_020185, VSP_020186; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in liver, placenta, and white blood cells. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Can functionally substitute for CWC12 in yeast (PubMed:19854871). SIMILARITY: Belongs to the CWC21 family. SEQUENCE CAUTION: Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:SRRM2 KIAA0324 SRL300 SRM300. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 2752 AA; 299615 MW; 7A5DCEB9B50AA912 CRC64;
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biopax3:name |
300 kDa nuclear matrix antigen,
SR-related nuclear matrix protein of 300 kDa,
SRRM2,
Ser/Arg-related nuclear matrix protein of 300 kDa,
Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,
Splicing coactivator subunit SRm300,
Tax-responsive enhancer element-binding protein 803,
TaxREB803
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