| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed. Expressed at high level in heart and skeletal muscle. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS. SIMILARITY: Belongs to the CSN3 family. SIMILARITY: Contains 1 PCI domain. SEQUENCE CAUTION: Sequence=AAC14197.1; Type=Erroneous initiation; GENE SYNONYMS:COPS3 CSN3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 423 AA; 47873 MW; 1D371050C7D7BF8D CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2239,
urn:biopax:RelationshipXref:NCBI GENE_8533,
urn:biopax:RelationshipXref:REFSEQ_NP_001186054,
urn:biopax:RelationshipXref:REFSEQ_NP_003644,
urn:biopax:UnificationXref:UNIPROT_B2R683,
urn:biopax:UnificationXref:UNIPROT_O43191,
urn:biopax:UnificationXref:UNIPROT_Q7LDR6,
urn:biopax:UnificationXref:UNIPROT_Q9UNS2
|
| biopax3:displayName |
CSN3_HUMAN
|
| biopax3:name |
COPS3,
JAB1-containing signalosome subunit 3,
SGN3,
Signalosome subunit 3
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
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| biopax3:standardName |
COP9 signalosome complex subunit 3
|