| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. SUBUNIT: May interact with PTPN6 via its ITIM motif. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UMR7-1; Sequence=Displayed; Name=2; IsoId=Q9UMR7-2; Sequence=VSP_012844; Name=3; Synonyms=llirV1; IsoId=Q9UMR7-3; Sequence=VSP_041348; Name=4; Synonyms=llirV2; IsoId=Q9UMR7-4; Sequence=VSP_012842; TISSUE SPECIFICITY: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). INDUCTION: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3, IL4/interleukin-4 and IL13/interleukin-13. DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. SIMILARITY: Contains 1 C-type lectin domain. SEQUENCE CAUTION: Sequence=AAL56016.1; Type=Frameshift; Positions=229; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=DCIR; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00137"; GENE SYNONYMS:CLEC4A CLECSF6 DCIR LLIR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 237 AA; 27512 MW; 1D07003E4C9CF96E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:13257,
urn:biopax:RelationshipXref:NCBI GENE_50856,
urn:biopax:RelationshipXref:REFSEQ_NP_057268,
urn:biopax:RelationshipXref:REFSEQ_NP_919429,
urn:biopax:RelationshipXref:REFSEQ_NP_919430,
urn:biopax:RelationshipXref:REFSEQ_NP_919432,
urn:biopax:UnificationXref:UNIPROT_Q17R69,
urn:biopax:UnificationXref:UNIPROT_Q8WXW9,
urn:biopax:UnificationXref:UNIPROT_Q9H2Z9,
urn:biopax:UnificationXref:UNIPROT_Q9NS33,
urn:biopax:UnificationXref:UNIPROT_Q9UI34,
urn:biopax:UnificationXref:UNIPROT_Q9UMR7
|
| biopax3:displayName |
CLC4A_HUMAN
|
| biopax3:name |
C-type lectin DDB27,
C-type lectin superfamily member 6,
CLEC4A,
Dendritic cell immunoreceptor,
Lectin-like immunoreceptor
|
| biopax3:organism | |
| biopax3:sequence |
MTSEITYAEVRFKNEFKSSGINTASSAASKERTAPHKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFFQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL
|
| biopax3:standardName |
C-type lectin domain family 4 member A
|