| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1- mediated APC/C activation. Interacts with USP37. Interacts (via WD repeats) with MAK. SUBCELLULAR LOCATION: Isoform 2: Nucleus. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UM11-1; Sequence=Displayed; Name=2; Synonyms=CDH1alpha, Fzr1; IsoId=Q9UM11-2; Sequence=VSP_008504; Note=Major; Name=3; Synonyms=CDH1beta, Fzr2; IsoId=Q9UM11-3; Sequence=VSP_008503, VSP_008504; Note=Minor; TISSUE SPECIFICITY: Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. PTM: Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK. SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=AAD26623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part; Sequence=AAD26624.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=BAA86556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:FZR1 CDH1 FYR FZR KIAA1242. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 496 AA; 55179 MW; F6C8FDAF81D8103A CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:24824,
urn:biopax:RelationshipXref:NCBI GENE_51343,
urn:biopax:RelationshipXref:REFSEQ_NP_001129669,
urn:biopax:RelationshipXref:REFSEQ_NP_001129670,
urn:biopax:RelationshipXref:REFSEQ_NP_057347,
urn:biopax:UnificationXref:UNIPROT_O75869,
urn:biopax:UnificationXref:UNIPROT_Q86U66,
urn:biopax:UnificationXref:UNIPROT_Q96NW8,
urn:biopax:UnificationXref:UNIPROT_Q9UI96,
urn:biopax:UnificationXref:UNIPROT_Q9ULH8,
urn:biopax:UnificationXref:UNIPROT_Q9UM10,
urn:biopax:UnificationXref:UNIPROT_Q9UM11,
urn:biopax:UnificationXref:UNIPROT_Q9UNQ1,
urn:biopax:UnificationXref:UNIPROT_Q9Y2T8
|
| biopax3:displayName |
FZR_HUMAN
|
| biopax3:name |
CDC20-like protein 1,
Cdh1/Hct1 homolog,
FZR1,
Fzr,
hCDH1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:FZR_HUMAN_1,
urn:biopax:ModificationFeature:FZR_HUMAN_10,
urn:biopax:ModificationFeature:FZR_HUMAN_2,
urn:biopax:ModificationFeature:FZR_HUMAN_3,
urn:biopax:ModificationFeature:FZR_HUMAN_4,
urn:biopax:ModificationFeature:FZR_HUMAN_5,
urn:biopax:ModificationFeature:FZR_HUMAN_6,
urn:biopax:ModificationFeature:FZR_HUMAN_7,
urn:biopax:ModificationFeature:FZR_HUMAN_8,
urn:biopax:ModificationFeature:FZR_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR
|
| biopax3:standardName |
Fizzy-related protein homolog
|