Linked Life Data

Q9ULZ3

Source:http://identifiers.org/uniprot/Q9ULZ3

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. SUBUNIT: Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1. SUBCELLULAR LOCATION: Cytoplasm. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ULZ3-1; Sequence=Displayed; Name=2; IsoId=Q9ULZ3-2; Sequence=VSP_004119; Name=3; IsoId=Q9ULZ3-3; Sequence=VSP_004118; Note=No experimental confirmation available; TISSUE SPECIFICITY: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T- cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells. DOMAIN: Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain. PTM: Phosphorylated. MISCELLANEOUS: In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death. SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 1 DAPIN domain. SEQUENCE CAUTION: Sequence=BAA91012.1; Type=Frameshift; Positions=4; GENE SYNONYMS:PYCARD ASC CARD5 TMS1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 195 AA; 21627 MW; 455987286586F46A CRC64;
biopax3:xref
biopax3:displayName
ASC_HUMAN
biopax3:name
Caspase recruitment domain-containing protein 5, PYCARD, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, hASC
biopax3:organism
biopax3:sequence
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
biopax3:standardName
Apoptosis-associated speck-like protein containing a CARD