| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. SUBUNIT: Interacts with AURKA. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. TISSUE SPECIFICITY: Expressed in lung carcinoma cell lines but not in normal lung tissues. DEVELOPMENTAL STAGE: Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TPX2 family. GENE SYNONYMS:TPX2 C20orf1 C20orf2 DIL2 HCA519. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 747 AA; 85653 MW; E028E0BB50BBCA0F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1249,
urn:biopax:RelationshipXref:NCBI GENE_22974,
urn:biopax:RelationshipXref:REFSEQ_NP_036244,
urn:biopax:UnificationXref:UNIPROT_Q9H1R4,
urn:biopax:UnificationXref:UNIPROT_Q9NRA3,
urn:biopax:UnificationXref:UNIPROT_Q9UFN9,
urn:biopax:UnificationXref:UNIPROT_Q9UL00,
urn:biopax:UnificationXref:UNIPROT_Q9ULW0,
urn:biopax:UnificationXref:UNIPROT_Q9Y2M1
|
| biopax3:displayName |
TPX2_HUMAN
|
| biopax3:name |
DIL-2,
Differentially expressed in cancerous and non-cancerous lung cells 2,
Hepatocellular carcinoma-associated antigen 519,
Protein fls353,
Restricted expression proliferation-associated protein 100,
TPX2,
p100
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:TPX2_HUMAN_1,
urn:biopax:ModificationFeature:TPX2_HUMAN_10,
urn:biopax:ModificationFeature:TPX2_HUMAN_11,
urn:biopax:ModificationFeature:TPX2_HUMAN_12,
urn:biopax:ModificationFeature:TPX2_HUMAN_13,
urn:biopax:ModificationFeature:TPX2_HUMAN_14,
urn:biopax:ModificationFeature:TPX2_HUMAN_15,
urn:biopax:ModificationFeature:TPX2_HUMAN_16,
urn:biopax:ModificationFeature:TPX2_HUMAN_17,
urn:biopax:ModificationFeature:TPX2_HUMAN_18,
urn:biopax:ModificationFeature:TPX2_HUMAN_19,
urn:biopax:ModificationFeature:TPX2_HUMAN_2,
urn:biopax:ModificationFeature:TPX2_HUMAN_20,
urn:biopax:ModificationFeature:TPX2_HUMAN_21,
urn:biopax:ModificationFeature:TPX2_HUMAN_22,
urn:biopax:ModificationFeature:TPX2_HUMAN_23,
urn:biopax:ModificationFeature:TPX2_HUMAN_24,
urn:biopax:ModificationFeature:TPX2_HUMAN_25,
urn:biopax:ModificationFeature:TPX2_HUMAN_26,
urn:biopax:ModificationFeature:TPX2_HUMAN_27,
urn:biopax:ModificationFeature:TPX2_HUMAN_28,
urn:biopax:ModificationFeature:TPX2_HUMAN_29,
urn:biopax:ModificationFeature:TPX2_HUMAN_3,
urn:biopax:ModificationFeature:TPX2_HUMAN_30,
urn:biopax:ModificationFeature:TPX2_HUMAN_31,
urn:biopax:ModificationFeature:TPX2_HUMAN_32,
urn:biopax:ModificationFeature:TPX2_HUMAN_4,
urn:biopax:ModificationFeature:TPX2_HUMAN_5,
urn:biopax:ModificationFeature:TPX2_HUMAN_6,
urn:biopax:ModificationFeature:TPX2_HUMAN_7,
urn:biopax:ModificationFeature:TPX2_HUMAN_8,
urn:biopax:ModificationFeature:TPX2_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC
|
| biopax3:standardName |
Targeting protein for Xklp2
|