| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation. SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CRY1 and CRY2. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 7 LRR (leucine-rich) repeats. GENE SYNONYMS:FBXL3 FBL3A FBXL3A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 428 AA; 48707 MW; AAEAB31BAF0EA5A5 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
FBXL3_HUMAN
|
| biopax3:name |
F-box and leucine-rich repeat protein 3A,
F-box/LRR-repeat protein 3A,
FBXL3
|
| biopax3:organism | |
| biopax3:sequence |
MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW
|
| biopax3:standardName |
F-box/LRR-repeat protein 3
|