| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May have a role in the control of cell proliferation. Appears to be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. SUBUNIT: Interacts with CDC6 and ORC2. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UJA3-1; Sequence=Displayed; Name=2; IsoId=Q9UJA3-2; Sequence=VSP_015785; Note=No experimental confirmation available; Name=3; IsoId=Q9UJA3-3; Sequence=VSP_041308; Note=No experimental confirmation available. According to Ref.2, this isoform could be derived from an aberrant mRNA form found in placental choriocarcinoma; TISSUE SPECIFICITY: Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. SIMILARITY: Belongs to the MCM family. SIMILARITY: Contains 1 MCM domain. SEQUENCE CAUTION: Sequence=BAB55260.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS:MCM8 C20orf154. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 840 AA; 93697 MW; 6349339A92FEBF88 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16147,
urn:biopax:RelationshipXref:NCBI GENE_84515,
urn:biopax:RelationshipXref:REFSEQ_NP_115874,
urn:biopax:RelationshipXref:REFSEQ_NP_877954,
urn:biopax:UnificationXref:UNIPROT_B2RBG7,
urn:biopax:UnificationXref:UNIPROT_D3DW08,
urn:biopax:UnificationXref:UNIPROT_Q495R4,
urn:biopax:UnificationXref:UNIPROT_Q495R7,
urn:biopax:UnificationXref:UNIPROT_Q86US4,
urn:biopax:UnificationXref:UNIPROT_Q969I5,
urn:biopax:UnificationXref:UNIPROT_Q9UJA3
|
| biopax3:displayName |
MCM8_HUMAN
|
| biopax3:name |
MCM8,
Minichromosome maintenance 8
|
| biopax3:organism | |
| biopax3:sequence |
MNGEYRGRGFGRGRFQSWKRGRGGGNFSGKWREREHRPDLSKTTGKRTSEQTPQFLLSTKTPQSMQSTLDRFIPYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM
|
| biopax3:standardName |
DNA replication licensing factor MCM8
|