| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. SUBUNIT: Homodimer (Probable). Interacts with RNF4 and JUN (By similarity). SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UGU0-1; Sequence=Displayed; Name=2; IsoId=Q9UGU0-2; Sequence=VSP_003984, VSP_003985; TISSUE SPECIFICITY: Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung. DOMAIN: The atypical PHD domain functions as a negative modulator of cofactor binding (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 A.T hook DNA-binding domain. SIMILARITY: Contains 1 PHD-type zinc finger. SEQUENCE CAUTION: Sequence=AAC36392.1; Type=Frameshift; Positions=1932; Sequence=CAB42440.1; Type=Erroneous initiation; GENE SYNONYMS:TCF20 KIAA0292 SPBP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1960 AA; 211771 MW; D3E34B1FAA6ED06F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11631,
urn:biopax:RelationshipXref:NCBI GENE_6942,
urn:biopax:RelationshipXref:REFSEQ_NP_005641,
urn:biopax:RelationshipXref:REFSEQ_NP_852469,
urn:biopax:UnificationXref:UNIPROT_A9JX12,
urn:biopax:UnificationXref:UNIPROT_O14528,
urn:biopax:UnificationXref:UNIPROT_Q13078,
urn:biopax:UnificationXref:UNIPROT_Q4V353,
urn:biopax:UnificationXref:UNIPROT_Q9H4M0,
urn:biopax:UnificationXref:UNIPROT_Q9UGU0
|
| biopax3:displayName |
TCF20_HUMAN
|
| biopax3:name |
Nuclear factor SPBP,
Protein AR1,
SPRE-binding protein,
Stromelysin-1 PDGF-responsive element-binding protein,
TCF-20,
TCF20
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:TCF20_HUMAN_1,
urn:biopax:ModificationFeature:TCF20_HUMAN_10,
urn:biopax:ModificationFeature:TCF20_HUMAN_11,
urn:biopax:ModificationFeature:TCF20_HUMAN_12,
urn:biopax:ModificationFeature:TCF20_HUMAN_13,
urn:biopax:ModificationFeature:TCF20_HUMAN_14,
urn:biopax:ModificationFeature:TCF20_HUMAN_15,
urn:biopax:ModificationFeature:TCF20_HUMAN_16,
urn:biopax:ModificationFeature:TCF20_HUMAN_17,
urn:biopax:ModificationFeature:TCF20_HUMAN_18,
urn:biopax:ModificationFeature:TCF20_HUMAN_19,
urn:biopax:ModificationFeature:TCF20_HUMAN_2,
urn:biopax:ModificationFeature:TCF20_HUMAN_20,
urn:biopax:ModificationFeature:TCF20_HUMAN_3,
urn:biopax:ModificationFeature:TCF20_HUMAN_4,
urn:biopax:ModificationFeature:TCF20_HUMAN_5,
urn:biopax:ModificationFeature:TCF20_HUMAN_6,
urn:biopax:ModificationFeature:TCF20_HUMAN_7,
urn:biopax:ModificationFeature:TCF20_HUMAN_8,
urn:biopax:ModificationFeature:TCF20_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMASETSGHQGYQGFRKEAGDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQPMQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNVNAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVRSPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKGGASEKAGSSPAQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKGSQEDDPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSKSPGSLRYSYKDSFGSAVPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNKSIGSLLENPHWGPWERKSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGRNDRLNPTLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGPQDSRPTPMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHTPFSPNSETLASAYHANTRAHAYGDPNAGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCWDLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRRVRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPAVTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAVQDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEEWRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQEGFPPKGYFPSGKKKGRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESKALPASSFMLQGPVVTESSVMGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCSHCQEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTEQSERG
|
| biopax3:standardName |
Transcription factor 20
|