| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. SUBUNIT: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with talin, actin, alpha- actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer. SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UGI8-1; Sequence=Displayed; Name=2; IsoId=Q9UGI8-2; Sequence=VSP_003122; TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX. SIMILARITY: Belongs to the prickle / espinas / testin family. SIMILARITY: Contains 3 LIM zinc-binding domains. SIMILARITY: Contains 1 PET domain. GENE SYNONYMS:TES. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 421 AA; 47996 MW; AB9FF6669C50D492 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:14620,
urn:biopax:RelationshipXref:NCBI GENE_26136,
urn:biopax:RelationshipXref:REFSEQ_NP_056456,
urn:biopax:RelationshipXref:REFSEQ_NP_690042,
urn:biopax:UnificationXref:UNIPROT_A4D0U6,
urn:biopax:UnificationXref:UNIPROT_Q9GZQ1,
urn:biopax:UnificationXref:UNIPROT_Q9HAJ9,
urn:biopax:UnificationXref:UNIPROT_Q9UGI8
|
| biopax3:displayName |
TES_HUMAN
|
| biopax3:name |
TES,
TESS
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
|
| biopax3:standardName |
Testin
|