| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. FUNCTION: Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. COFACTOR: Calcium. Required for high affinity binding to GABA. SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. SUBCELLULAR LOCATION: Isoform 1E: Secreted (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Comment=Isoforms corresponding to the full receptor are essentially found in the central nervous system (CNS); Name=1A; IsoId=Q9UBS5-1; Sequence=Displayed; Name=1B; IsoId=Q9UBS5-2; Sequence=VSP_002037; Name=1C; IsoId=Q9UBS5-3; Sequence=VSP_002038; Name=1D; IsoId=Q9UBS5-4; Sequence=VSP_002040; Name=1E; Synonyms=Truncated; IsoId=Q9UBS5-5; Sequence=VSP_002039; Note=Major isoform in almost all peripheral tissues, although containing a premature stop codon in the mRNA and thus being a potential target for nonsense-mediated mRNA decay. May act as an antagonist of GABA-B receptors, being able to disrupt the normal association between isoform 1A and GABA-B-R2; TISSUE SPECIFICITY: Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. DOMAIN: Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. SIMILARITY: Contains 2 Sushi (CCP/SCR) domains. GENE SYNONYMS:GABBR1 GPRC3A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 961 AA; 108320 MW; 54E7349CD02B633F CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4070,
urn:biopax:RelationshipXref:NCBI GENE_2550,
urn:biopax:RelationshipXref:REFSEQ_NP_001461,
urn:biopax:RelationshipXref:REFSEQ_NP_068703,
urn:biopax:RelationshipXref:REFSEQ_NP_068704,
urn:biopax:UnificationXref:UNIPROT_B0UXY7,
urn:biopax:UnificationXref:UNIPROT_O95375,
urn:biopax:UnificationXref:UNIPROT_O95468,
urn:biopax:UnificationXref:UNIPROT_O95975,
urn:biopax:UnificationXref:UNIPROT_O96022,
urn:biopax:UnificationXref:UNIPROT_Q5STL4,
urn:biopax:UnificationXref:UNIPROT_Q5SUJ8,
urn:biopax:UnificationXref:UNIPROT_Q5SUL3,
urn:biopax:UnificationXref:UNIPROT_Q86W60,
urn:biopax:UnificationXref:UNIPROT_Q9UBS5,
urn:biopax:UnificationXref:UNIPROT_Q9UQQ0
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| biopax3:displayName |
GABR1_HUMAN
|
| biopax3:name |
GABA-B receptor 1,
GABA-B-R1,
GABA-BR1,
GABABR1,
GABBR1,
Gb1
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| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
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| biopax3:standardName |
Gamma-aminobutyric acid type B receptor subunit 1
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