| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. SUBUNIT: Interacts with RAF1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). TISSUE SPECIFICITY: In adult, highly expressed in brain, lung, heart and at lower levels in skeletal muscle and kidney. In embryo, highly expressed in lung epithelial cells, primarily in the distal airways. DEVELOPMENTAL STAGE: At E8.5 expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain. At E9.5 continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud. At E10.5 expressed in the somites, frontonasal processes, tailbud, and hindlimb bud. INDUCTION: By FGF signaling. DOMAIN: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. SIMILARITY: Belongs to the sprouty family. SIMILARITY: Contains 1 SPR (sprouty) domain. GENE SYNONYMS:Spry2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 315 AA; 34623 MW; 81514698EAD809A7 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
SPY2_MOUSE
|
| biopax3:name |
Spry-2,
Spry2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MEARAQSGNGSQPLLQTAHDSGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPSQVHSSRAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGPSFSHGPAAADGIIRVQPKSELKPGDVKPLSKDDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
|
| biopax3:standardName |
Protein sprouty homolog 2
|