| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcription factor. Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. May play a role in development. May be involved in epidermal differentiation (By similarity). Binds and transactivates the EN1 promoter. SUBUNIT: Homodimer, also forms heterodimers with GRHL2 or GRHL3. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=p70 MGR; IsoId=Q9NZI5-1; Sequence=Displayed; Name=2; Synonyms=p49 MGR; IsoId=Q9NZI5-2; Sequence=VSP_017636, VSP_017637; Name=3; IsoId=Q9NZI5-3; Sequence=VSP_017638, VSP_017639; Note=No experimental confirmation available; TISSUE SPECIFICITY: Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Highly expressed in placental JEG-3 cells and at very low levels in non-steroidogenic cells. No expression detected in adrenal NCI-H295A cells. DEVELOPMENTAL STAGE: Expressed in fetal liver and brain. SIMILARITY: Belongs to the grh/CP2 family. Grainyhead subfamily. GENE SYNONYMS:GRHL1 LBP32 MGR TFCP2L2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 618 AA; 70113 MW; 449587B17F4A8A44 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:17923,
urn:biopax:RelationshipXref:NCBI GENE_29841,
urn:biopax:RelationshipXref:REFSEQ_NP_937825,
urn:biopax:UnificationXref:UNIPROT_A6NLA4,
urn:biopax:UnificationXref:UNIPROT_B2R7E4,
urn:biopax:UnificationXref:UNIPROT_B5MEC2,
urn:biopax:UnificationXref:UNIPROT_Q53T93,
urn:biopax:UnificationXref:UNIPROT_Q6NWN7,
urn:biopax:UnificationXref:UNIPROT_Q6NWN8,
urn:biopax:UnificationXref:UNIPROT_Q6NWN9,
urn:biopax:UnificationXref:UNIPROT_Q8NI33,
urn:biopax:UnificationXref:UNIPROT_Q9NZI5
|
| biopax3:displayName |
GRHL1_HUMAN
|
| biopax3:name |
GRHL1,
Mammalian grainyhead,
NH32,
Transcription factor CP2-like 2,
Transcription factor LBP-32
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPTERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFANLQRGTHVLPIASEELEGEGSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI
|
| biopax3:standardName |
Grainyhead-like protein 1 homolog
|