| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. SUBUNIT: Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200 (By similarity). Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9NZ52-1; Sequence=Displayed; Name=Short; IsoId=Q9NZ52-2; Sequence=VSP_001745; TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif). DOMAIN: The GAT domain is responsible for interaction with ARF- GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis. DOMAIN: The unstructured hinge region contains clathrin-binding and an autoinhibitory (AC-LL) motifs. DOMAIN: The GAE domain binds accessory proteins regulating GGAs function. PTM: Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals. PTM: Ubiquitinated. SIMILARITY: Belongs to the GGA protein family. SIMILARITY: Contains 1 GAE domain. SIMILARITY: Contains 1 GAT domain. SIMILARITY: Contains 1 VHS domain. SEQUENCE CAUTION: Sequence=BAA09926.1; Type=Erroneous initiation; GENE SYNONYMS:GGA3 KIAA0154. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 723 AA; 78315 MW; 4F80D6032239168C CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:17079,
urn:biopax:RelationshipXref:NCBI GENE_23163,
urn:biopax:RelationshipXref:REFSEQ_NP_001166174,
urn:biopax:RelationshipXref:REFSEQ_NP_054720,
urn:biopax:RelationshipXref:REFSEQ_NP_619525,
urn:biopax:UnificationXref:UNIPROT_Q15017,
urn:biopax:UnificationXref:UNIPROT_Q6IS16,
urn:biopax:UnificationXref:UNIPROT_Q9NZ52,
urn:biopax:UnificationXref:UNIPROT_Q9UJY3
|
| biopax3:displayName |
GGA3_HUMAN
|
| biopax3:name |
GGA3,
Golgi-localized, gamma ear-containing, ARF-binding protein 3
|
| biopax3:organism | |
| biopax3:sequence |
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
|
| biopax3:standardName |
ADP-ribosylation factor-binding protein GGA3
|