| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity). SUBUNIT: Interacts with TWISTNB, EIF3L, TAF1B and TAF1C. SUBCELLULAR LOCATION: Nucleus, nucleolus. PTM: Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation. SIMILARITY: Belongs to the RRN3 family. GENE SYNONYMS:RRN3 TIFIA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 651 AA; 74107 MW; C646DC6677C49895 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:30346,
urn:biopax:RelationshipXref:NCBI GENE_54700,
urn:biopax:RelationshipXref:REFSEQ_NP_060897,
urn:biopax:UnificationXref:UNIPROT_A2RTY9,
urn:biopax:UnificationXref:UNIPROT_Q6IPL4,
urn:biopax:UnificationXref:UNIPROT_Q9H4F0,
urn:biopax:UnificationXref:UNIPROT_Q9NYV6
|
| biopax3:displayName |
RRN3_HUMAN
|
| biopax3:name |
RRN3,
TIF-IA,
Transcription initiation factor IA
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAAPLLHTRLPGDAAASSSAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLLDPDIKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDDNLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVNASRQGIEDAEETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLDQMVHPVAERLDILMSLVLSYMKDVCYVDGKVDNGKTKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRQMLPVIRSTAGGDSVQICTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMSAEELQEFKKPMKKDIVEDEDDDFLKGEVPQNDTVIGITPSSFDTHFRSPSSSVGSPPVLYMQPSPL
|
| biopax3:standardName |
RNA polymerase I-specific transcription initiation factor RRN3
|