| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. CATALYTIC ACTIVITY: Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains. SUBCELLULAR LOCATION: Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NX52-1; Sequence=Displayed; Name=2; IsoId=Q9NX52-3; Sequence=VSP_012692; Note=May be due to an intron retention. No experimental confirmation available; PTM: Proteolytic processing of the proenzyme produces a N-terminal fragment (NTF) and a C-terminal fragment (CTF). The processing is required for activation of the protease. SIMILARITY: Belongs to the peptidase S54 family. SEQUENCE CAUTION: Sequence=AAH13103.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91168.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS:RHBDL2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 303 AA; 34021 MW; 2B6CB8291319C2D9 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16083,
urn:biopax:RelationshipXref:NCBI GENE_54933,
urn:biopax:RelationshipXref:REFSEQ_NP_060291,
urn:biopax:UnificationXref:UNIPROT_B2RNT3,
urn:biopax:UnificationXref:UNIPROT_B9EH75,
urn:biopax:UnificationXref:UNIPROT_Q6P175,
urn:biopax:UnificationXref:UNIPROT_Q8NER8,
urn:biopax:UnificationXref:UNIPROT_Q96E02,
urn:biopax:UnificationXref:UNIPROT_Q9NX52
|
| biopax3:displayName |
RHBL2_HUMAN
|
| biopax3:name |
3.4.21.105,
CTF,
NTF,
RHBDL2,
RRP2,
Rhomboid-like protein 2,
Rhomboid-related protein 2, C-terminal fragment,
Rhomboid-related protein 2, N-terminal fragment
|
| biopax3:organism | |
| biopax3:sequence |
MAAVHDLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLSPAN
|
| biopax3:standardName |
Rhomboid-related protein 2
|