| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'- GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor. SUBUNIT: Interacts with RASA1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRY4-1; Sequence=Displayed; Name=2; IsoId=Q9NRY4-2; Sequence=VSP_007105; PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. SIMILARITY: Contains 4 FF domains. SIMILARITY: Contains 1 Rho-GAP domain. SEQUENCE CAUTION: Sequence=AAA58618.1; Type=Frameshift; Positions=389, 533, 540, 607, 614, 1167, 1241, 1292, 1334, 1446; Sequence=AAF80386.1; Type=Frameshift; Positions=533, 540, 607, 614; GENE SYNONYMS:ARHGAP35 GRF1 GRLF1 KIAA1722. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1513 AA; 172229 MW; 305C2B3D06519F96 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4591,
urn:biopax:RelationshipXref:NCBI GENE_2909,
urn:biopax:RelationshipXref:REFSEQ_NP_004482,
urn:biopax:UnificationXref:UNIPROT_A7E2A4,
urn:biopax:UnificationXref:UNIPROT_Q14452,
urn:biopax:UnificationXref:UNIPROT_Q9C0E1,
urn:biopax:UnificationXref:UNIPROT_Q9NRY4
|
| biopax3:displayName |
RHG35_HUMAN
|
| biopax3:name |
ARHGAP35,
GRF-1,
Glucocorticoid receptor DNA-binding factor 1,
Glucocorticoid receptor repression factor 1,
Rho GAP p190A,
p190-A
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:RHG35_HUMAN_1,
urn:biopax:ModificationFeature:RHG35_HUMAN_10,
urn:biopax:ModificationFeature:RHG35_HUMAN_11,
urn:biopax:ModificationFeature:RHG35_HUMAN_12,
urn:biopax:ModificationFeature:RHG35_HUMAN_13,
urn:biopax:ModificationFeature:RHG35_HUMAN_14,
urn:biopax:ModificationFeature:RHG35_HUMAN_2,
urn:biopax:ModificationFeature:RHG35_HUMAN_3,
urn:biopax:ModificationFeature:RHG35_HUMAN_4,
urn:biopax:ModificationFeature:RHG35_HUMAN_5,
urn:biopax:ModificationFeature:RHG35_HUMAN_6,
urn:biopax:ModificationFeature:RHG35_HUMAN_7,
urn:biopax:ModificationFeature:RHG35_HUMAN_8,
urn:biopax:ModificationFeature:RHG35_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVSRSLEDCVECKMHIVEQTEFIDDQTFQPHRSTALQPYIKRAAATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKFVSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKIIPYFEALKQQSQQIATAKDKYEWLVSRIVKNHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDHLSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHLEKLRNERKRVEMRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAERDALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDDKYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQGQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADVDLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELSVLSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDLSREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPSYSLFREDTSLPSLSKDHSKLSMELEGNDGLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQDGFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERGRKVSIVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSPLHPHRPTPQPSRNIPWQTKEH
|
| biopax3:standardName |
Rho GTPase-activating protein 35
|