| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. COFACTOR: Calcium (By similarity). SUBUNIT: Interacts with PDCD6. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRQ2-1; Sequence=Displayed; Name=2; IsoId=Q9NRQ2-2; Sequence=VSP_042931, VSP_042932; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes. SIMILARITY: Belongs to the phospholipid scramblase family. SEQUENCE CAUTION: Sequence=AAP97186.1; Type=Frameshift; Positions=152, 155, 163, 325; GENE SYNONYMS:PLSCR4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 329 AA; 37005 MW; 12BE86728D54F794 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16497,
urn:biopax:RelationshipXref:NCBI GENE_57088,
urn:biopax:RelationshipXref:REFSEQ_NP_001121778,
urn:biopax:RelationshipXref:REFSEQ_NP_001170775,
urn:biopax:RelationshipXref:REFSEQ_NP_065086,
urn:biopax:UnificationXref:UNIPROT_A8K2E9,
urn:biopax:UnificationXref:UNIPROT_Q2TTR3,
urn:biopax:UnificationXref:UNIPROT_Q658L3,
urn:biopax:UnificationXref:UNIPROT_Q6ZR73,
urn:biopax:UnificationXref:UNIPROT_Q7Z505,
urn:biopax:UnificationXref:UNIPROT_Q9NRQ2
|
| biopax3:displayName |
PLS4_HUMAN
|
| biopax3:name |
Ca(2+)-dependent phospholipid scramblase 4,
Cell growth-inhibiting gene 43 protein,
PL scramblase 4,
PLSCR4,
TRA1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGYYSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQLDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDCMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHFDIHFPLDLDVKMKAMIFGACFLIDFMYFERSPPQRSR
|
| biopax3:standardName |
Phospholipid scramblase 4
|