| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activates progelatinase B. COFACTOR: Binds 1 zinc ion per subunit (By similarity). COFACTOR: Calcium (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines. DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. SIMILARITY: Belongs to the peptidase M10A family. GENE SYNONYMS:MMP26. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 261 AA; 29708 MW; A66D0DBE3ED7DE76 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:14249,
urn:biopax:RelationshipXref:NCBI GENE_56547,
urn:biopax:RelationshipXref:REFSEQ_NP_068573,
urn:biopax:UnificationXref:UNIPROT_Q3MJ78,
urn:biopax:UnificationXref:UNIPROT_Q9GZS2,
urn:biopax:UnificationXref:UNIPROT_Q9NR87,
urn:biopax:UnificationXref:UNIPROT_Q9NRE1
|
| biopax3:displayName |
MMP26_HUMAN
|
| biopax3:name |
3.4.24.-,
Endometase,
MMP-26,
MMP26,
Matrilysin-2
|
| biopax3:organism | |
| biopax3:sequence |
MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDIP
|
| biopax3:standardName |
Matrix metalloproteinase-26
|