| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. SUBUNIT: Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist; Name=1; Synonyms=A; IsoId=Q9NR96-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9NR96-2; Sequence=VSP_006520; Name=3; IsoId=Q9NR96-3; Sequence=VSP_006521; Name=4; IsoId=Q9NR96-4; Sequence=VSP_006522; Name=5; IsoId=Q9NR96-5; Sequence=VSP_006523; TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 26 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 TIR domain. GENE SYNONYMS:TLR9. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1032 AA; 115860 MW; 71280AA9680EDCE2 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:15633,
urn:biopax:RelationshipXref:NCBI GENE_54106,
urn:biopax:RelationshipXref:REFSEQ_NP_059138,
urn:biopax:UnificationXref:UNIPROT_B3Y661,
urn:biopax:UnificationXref:UNIPROT_Q6UVZ2,
urn:biopax:UnificationXref:UNIPROT_Q9HD68,
urn:biopax:UnificationXref:UNIPROT_Q9HD69,
urn:biopax:UnificationXref:UNIPROT_Q9HD70,
urn:biopax:UnificationXref:UNIPROT_Q9NR96,
urn:biopax:UnificationXref:UNIPROT_Q9NYC2,
urn:biopax:UnificationXref:UNIPROT_Q9NYC3
|
| biopax3:displayName |
TLR9_HUMAN
|
| biopax3:name |
CD289,
TLR9
|
| biopax3:organism | |
| biopax3:sequence |
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE
|
| biopax3:standardName |
Toll-like receptor 9
|