| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBUNIT: Interacts with L3MBTL1. SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQR1-1; Sequence=Displayed; Name=2; IsoId=Q9NQR1-2; Sequence=VSP_002226, VSP_002227; DEVELOPMENTAL STAGE: Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level). INDUCTION: By HCFC1 C-terminal chain, independently of HCFC1 N- terminal chain. DOMAIN: Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity. SIMILARITY: Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. SIMILARITY: Contains 1 SET domain. CAUTION: It is uncertain whether Met-1 or Met-72 is the initiator. SEQUENCE CAUTION: Sequence=AAL40879.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS:SETD8 KMT5A PRSET7 SET07 SET8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 393 AA; 42890 MW; 2DCD9B697834B5BD CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:29489,
urn:biopax:RelationshipXref:NCBI GENE_387893,
urn:biopax:RelationshipXref:REFSEQ_NP_065115,
urn:biopax:UnificationXref:UNIPROT_A8K9D0,
urn:biopax:UnificationXref:UNIPROT_Q86W83,
urn:biopax:UnificationXref:UNIPROT_Q8TD09,
urn:biopax:UnificationXref:UNIPROT_Q9NQR1
|
| biopax3:displayName |
SETD8_HUMAN
|
| biopax3:name |
2.1.1.-,
2.1.1.43,
H4-K20-HMTase SETD8,
Histone-lysine N-methyltransferase SETD8,
Lysine N-methyltransferase 5A,
PR-Set7,
PR/SET domain-containing protein 07,
PR/SET07,
SET domain-containing protein 8,
SETD8
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
|
| biopax3:standardName |
N-lysine methyltransferase SETD8
|