| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). ENZYME REGULATION: Activated by WNK3. SUBUNIT: Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity). SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. PTM: Glycosylated. SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily. SIMILARITY: Contains 5 ANK repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/trpv5/"; GENE SYNONYMS:TRPV5 ECAC1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 729 AA; 82551 MW; A10FB80205FD0DBB CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:3145,
urn:biopax:RelationshipXref:NCBI GENE_56302,
urn:biopax:RelationshipXref:REFSEQ_NP_062815,
urn:biopax:UnificationXref:UNIPROT_A4D2H7,
urn:biopax:UnificationXref:UNIPROT_Q8NDW5,
urn:biopax:UnificationXref:UNIPROT_Q8NDX7,
urn:biopax:UnificationXref:UNIPROT_Q8NDX8,
urn:biopax:UnificationXref:UNIPROT_Q96PM6,
urn:biopax:UnificationXref:UNIPROT_Q9NQA5
|
| biopax3:displayName |
TRPV5_HUMAN
|
| biopax3:name |
CaT2,
Calcium transport protein 2,
ECaC,
ECaC1,
Epithelial calcium channel 1,
OTRPC3,
Osm-9-like TRP channel 3,
TRPV5,
TrpV5
|
| biopax3:organism | |
| biopax3:sequence |
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF
|
| biopax3:standardName |
Transient receptor potential cation channel subfamily V member 5
|