| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in the promotion of apoptosis. SUBUNIT: Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. SUBCELLULAR LOCATION: Cytoplasm. Note=Cytoplasmic filaments. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CLANA; IsoId=Q9NPP4-1; Sequence=Displayed; Name=2; Synonyms=CLANB; IsoId=Q9NPP4-2; Sequence=VSP_000784; Name=3; Synonyms=CLANC; IsoId=Q9NPP4-3; Sequence=VSP_000785, VSP_000786; Name=4; Synonyms=CLAND; IsoId=Q9NPP4-4; Sequence=VSP_000787, VSP_000788; TISSUE SPECIFICITY: Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain. SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 14 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 NACHT domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NLRC4ID43189ch2p22.html"; GENE SYNONYMS:NLRC4 CARD12 CLAN CLAN1 IPAF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1024 AA; 116159 MW; 49378DBB54938E0F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16412,
urn:biopax:RelationshipXref:NCBI GENE_58484,
urn:biopax:RelationshipXref:REFSEQ_NP_001186067,
urn:biopax:RelationshipXref:REFSEQ_NP_001186068,
urn:biopax:RelationshipXref:REFSEQ_NP_067032,
urn:biopax:UnificationXref:UNIPROT_B2RBQ3,
urn:biopax:UnificationXref:UNIPROT_D6W580,
urn:biopax:UnificationXref:UNIPROT_Q96J81,
urn:biopax:UnificationXref:UNIPROT_Q96J82,
urn:biopax:UnificationXref:UNIPROT_Q96J83,
urn:biopax:UnificationXref:UNIPROT_Q9NPP4
|
| biopax3:displayName |
NLRC4_HUMAN
|
| biopax3:name |
CARD, LRR, and NACHT-containing protein,
Caspase recruitment domain-containing protein 12,
Clan protein,
Ice protease-activating factor,
Ipaf,
NLRC4
|
| biopax3:organism | |
| biopax3:sequence |
MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA
|
| biopax3:standardName |
NLR family CARD domain-containing protein 4
|