| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. SUBUNIT: Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2. SUBCELLULAR LOCATION: Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. SIMILARITY: Belongs to the DCP1 family. GENE SYNONYMS:DCP1A SMIF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 582 AA; 63309 MW; D218180ABA7FD768 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
DCP1A_HUMAN
|
| biopax3:name |
3.-.-.-,
DCP1A,
Smad4-interacting transcriptional co-activator,
Transcription factor SMIF
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:DCP1A_HUMAN_1,
urn:biopax:ModificationFeature:DCP1A_HUMAN_10,
urn:biopax:ModificationFeature:DCP1A_HUMAN_11,
urn:biopax:ModificationFeature:DCP1A_HUMAN_2,
urn:biopax:ModificationFeature:DCP1A_HUMAN_3,
urn:biopax:ModificationFeature:DCP1A_HUMAN_4,
urn:biopax:ModificationFeature:DCP1A_HUMAN_5,
urn:biopax:ModificationFeature:DCP1A_HUMAN_6,
urn:biopax:ModificationFeature:DCP1A_HUMAN_7,
urn:biopax:ModificationFeature:DCP1A_HUMAN_8,
urn:biopax:ModificationFeature:DCP1A_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIQVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
|
| biopax3:standardName |
mRNA-decapping enzyme 1A
|